Cancer Immunotherapy and Genomics Lab

The Steinhart Lab aims to decode how tumors suppress T cell function and leverage these insights to design new immunotherapies for treatment-resistant cancers, with an emphasis on Head and Neck Cancer. By combining CRISPR-based functional genomics with primary human models, including patient-derived TILs and tumor organoids, we seek to identify the tumor signals and genetic programs that drive T cell dysfunction and reveal actionable pathways to restore durable antitumor immunity.

We are located in the Helen Diller Family Comprehensive Cancer Center (HDFCCC) at UCSF’s Mission Bay campus. UCSF is a world-class biomedical research university with outstanding Immunology, Cancer, and Genomics research communities enabling strongly collaborative research.