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Research

(415) 885-7700

UCSF Voice & Swallowing Center Presentations

2020 Virtual Fall Voice Conference

Laryngeal Electromyography Abnormal Findings In Asymptomatic Adults Across The Age SP

Remote Voice Testing Fall Voice 2020 Final

  • Creation and Implementation of the UCSF Laryngeal Symptom Diary (PDF)
  • Novel Application of Quantitative Electromyography to Guide Botulinum Toxin Injection for Spasmodic Dysphonia (PDF)
  • Cultural Adaptation and Validation of Speech Handicap Index (SHI): A Scoping Review (PDF)
  • Association Between Quality of Life Questionnaires: Towards Laryngology PROM Reduction (PDF)
  • Voice and Stroboscopic Characteristics in Transgender Patients Seeking Gender-Affirming Voice Care (PDF)

Ongoing Research

Laryngopharyngeal Sensory Testing

Disorders: Normal subjects, Dysphagia, Spasmodic Dysphonia, Vocal Fold Paralysis

Eligible Subjects:

Information: Altered sensation of the throat and voice box (increased or decreased) is thought to be an important factor in many different voice and swallowing disorders. Currently, testing of sensation in these areas has been difficult and non-standardized. Our group has developed and validated a novel tool to test sensation of the throat and voice box. We will be recruiting patients with various voice and swallowing disorders to investigate and assess for the potential role of abnormal sensation.

Abstract Factors Predicting the Likelihood of Subsequent Research Publication

Disorders: Variable

Eligible Subjects: N/A

Information: Research is an important component of medicine, and contributes to our understanding of various diseases and their treatment. Each year, many different research projects and abstracts are submitted to conferences and meetings for presentation, but many of these are subsequently never published. We aim to identify factors contained in submitted abstract that can predict the likelihood of eventual publication in high quality medical journals.

Validating a Method of Remote Voice Testing

Disorders: n/a

Eligible Subjects: Healthy adults without voice complaints

Information: The gold standard voice laboratory recording, landline voicemail and voice memos on a smart phone will be used to record standard voice tasks in healthy adults. Analysis of the voice samples from the different devices will be completed and results will be analyzed to determine if remote voice recordings are comparable to the gold standard and adequate to measure voice outcomes. This could impact our ability to complete larger scale voice outcomes research and perform distinct voice analysis by allowing us to track measures remotely reducing the patient, provider and researcher burden related to clinic travel, time spent in clinic, and coordination of schedules.

Correlation Between Montreal Cognitive Assessment (MoCA) and Voice Therapy Outcomes in the Aging Treatment-Seeking Population

Disorders: Vocal fold atrophy

Eligible Subjects: English-speaking patients aged 60 years and older who are seeking care for a laryngological disorder and candidates for voice therapy

Information: We are investigating if the performance on the Montreal Cognitive Assessment (MoCA) is associated or predictive of the outcomes in voice therapy in the older larynogology treatment seeking patients. The relationship between the scores of MoCA and parameters in voice therapy will be analyzed. The outcomes of this study could potentially impact how we determine candidacy for voice therapy and develop patient treatment plans to meet their needs. This is a collaborative study with Emory Voice Center and the NYU Voice Center.

Association Between Quality of Life Questionnaires in Patients Seen at a Voice and Swallowing Center

Disorders: Airway, Voice and Swallowing

Eligible Subjects: Any patient with an airway, voice or swallowing condition

Information: Laryngology outcomes focus primarily on patient reported outcome measures (PROMs). Increasing the number of questionnaires leads to survey fatigue and reliability of patient responses. We are looking to determine overlaps and redundancies between the current questionnaires given to patients seen at our Voice and Swallowing Center.

Application of Speech Handicap Index (SHI) in Patients After Total Laryngectomy in America and SHI Item Reduction [Fulbright Scholar’s Project]

Disorders: Head and neck cancer patients, specifically laryngeal cancer

Eligible Subjects: Patients after Total Laryngectomy

Information: The goal of this study is to assess speech in patients after total laryngectomy in America using the patient-reported Speech Handicap Index (SHI). This study will also determine the cut-off score of the Speech Handicap Index (SHI) which will aid in the evaluation and treatment process to determine handicap and track over time. Additionally, we will complete item reduction of SHI in the English-speaking population in America to reduce the length of the questionnaire for future patients.

Superior Laryngeal Nerve Block for the Treatment of Unexplained Chronic Cough

Disorders: Chronic Cough

Eligible Subjects: Adult patients with cough (greater than 3 months total duration) not adequately controlled with medications or cough therapy

Information: Chronic cough is a bothersome symptom. Sometimes, despite many investigations, specialist referrals, and medication trials/therapies, the cough persists. This is called unexplained chronic cough. We are investigating the use of a novel treatment option called a superior laryngeal nerve block. With this procedure, a steroid-lidocaine injection around the nerve controlling sensation to the voice box is performed.

Recurrent Respiratory Papillomatosis (Heatmap) Study

Disorders: Recurrent Respiratory Papillomatosis

Eligible Subjects: Adult patients with laryngeal papilloma (Recurrent Respiratory Papillomatosis)

Information: This study aims to describe the location of papilloma growth across different regions of the voice box over time and following treatment. Your treating doctor will document papilloma growth and location at each of your regular clinic visits, and collect information on the type and number of surgeries needed to treat your condition. No experimental procedures will take place or extra clinic visits. This study is being done with the NYU Voice Center supporting the innovative RRP mapping technique developed at the NYU Voice Center (Milan Amin, MD).

Publications

Creation and Implementation of a Laryngologic Symptom Diary for Trial Vocal Fold Injection

Disorders: Vocal Fold Atrophy, Scar, Paresis, Sulcus, Essential Tremor, Cricoarytenoid Joint Fixation, Chronic Cough

Eligible Subjects: Adult patients with various Voice disorders undergoing trial vocal fold injection augmentation

Information: Certain voice conditions are difficult to treat, and one potential treatment option is a trial vocal fold augmentation. A temporary gel filler is injected into the vocal fold(s), and the patient is reports back to the physician after 4-12 weeks how much their voice improved with the injection. We have created and are validating a “Voice Diary” to assist patients in documenting and tracking the aspects of their voice that change following this trial injection. This will help decision making by enhancing accuracy of patient recall.

Pubmed link

Using Qualitative Electromyography to Guide Botulinum Toxin Injection for Spasmodic Dysphonia

Disorders: Abductor Spasmodic Dysphonia

Eligible Subjects: Adult patients with abductor spasmodic dysphonia who seek Botox treatment

Information: EMG is a tool used by laryngologists to inject Botox for the treatment of spasmodic dysphonia. Currently, EMG is used qualitatively (based on how the signal “sounds”). We are investigating using EMG quantitatively (based on the numbers and data generated by the EMG machine) to more accurately and consistently inject Botox for our SD patients. This method will especially help less experienced Botox injectors.

Pubmed link