Recently, a multidisciplinary team of investigators from the UC-San Francisco Departments of Otolaryngology–Head and Neck Surgery (OHNS), Radiology and Biomedical Imaging, and Pathology and Laboratory Medicine sought to answer the question: "Among patients with HPV+OPSCC, how common are the post-surgical histopathologic features that suggest the use of adjuvant radiotherapy or adjuvant chemoradiotherapy after surgery?"