Seminar: Precise Patterning in the Mammalian Inner Ear

January 24, 2020 - 12:30pm to 1:30pm
Rock Hall – Pottruck Auditorium Mission Bay – Rock Hall Building - 1550 4th Street - San Francisco - CA 94158

David Sprinzak, Ph.D.

Associate Professor
Department of Biochemistry and Molecular Biology
Tel Aviv University


Precise Patterning in the Mammalian Inner Ear

Precise periodic organization of cells is required for the function of many organs and tissues. The development of such periodic patterns is typically associated with mechanisms based on intercellular signaling such as lateral inhibition and Turing patterning. Here we show that the transition from disordered to ordered checkerboard-like pattern of hair cells and supporting cells in the mammalian hearing organ, the organ of Corti, is based on mechanical forces rather than signaling events. Using time-lapse imaging of mouse cochlear explants, we show that hair cells rearrange gradually into a precise checkerboard-like pattern through a tissue-wide shear motion that coordinates intercalation and delamination events. Using mechanical models of the tissue, we show that global shear and local repulsion forces on hair cells are sufficient to drive the transition from disordered to ordered cellular pattern. Our findings suggest that mechanical forces drive precise hair cell patterning in a process strikingly analogous to the process of shear-induced crystallization in polymer and granular physics.


Rock Hall Pottruck Auditorium
January 24, 2020


Young-wook Jun ([email protected]), Host

Light lunch including pizza and coffee will be provided.
This seminar is sponsored by Department of Otolaryngology – Head and Neck Surgery.