Clinical Trials

UCSF Otolaryngology has an exciting tradition of innovative clinical research that advances medical knowledge and improves the lives of patients. Clinical studies are conducted with volunteer participants. Prior to trial approval, the research protocol is reviewed by the Institutional Research Board (IRB) to ensure all studies are ethical and scientifically sound. Studies require informed consent from the participating subjects.

Clinical studies are led by a principal investigator who leads a research team that may include fellow clinician-scientists, collaborators, and research coordinators.

In addition to clinical studies, UCSF Otolaryngology clinician-scientists use observational studies to study outcomes in groups of participants. These type of studies can include focused medical records reviews, collections of pathological samples, large database analysis, and more.

 

 

Airway, Voice, and Swallowing

Autologous Muscle Derived Cells for Treatment of Tongue Dysphagia

The primary objective of this double-blind, randomized, placebo-controlled, multicenter clinical trial is to evaluate the safety of Autologous Muscle Derived Cells for Gastro-Intestinal Repair (AMDC-GIR) during the 24 months following 2 consecutive treatments of tongue dysphagia in male and female patients who have undergone surgery and/or chemo- and/or radiotherapy for squamous cell cancer of the oropharynx.

Click here for more information. Click here for a short video about the study.

Study Number

NCT05421689

Key individuals

Principal Investigator
Clark Rosen, MD

Contact Information

 

Balance and Falls

Current Studies

Please go to the Balance & Falls Center Research page, to learn more.

Key Individuals

Principal Investigator: Jeffery Sharon, MD
Study Coordinator: Maxwell Hum ([email protected])

Head and Neck Oncology

 

Pediatric Otolaryngology

 

 

Comparison of pure-tone audiometric and otoacoustic emission testing for hearing loss in pre-school-aged children

Early identification and intervention for hearing loss in children is critical to prevent future speech, language, educational, and cognitive impairment. Though universal newborn hearing screening has been highly successful at identifying deaf and hard of hearing babies at birth, there is no subsequent mechanism for hearing screening until the start of school. Currently, preschool hearing screening is highly variable, and outcomes are uncertain. We have partnered with the San Francisco Department of Public Health to optimize screening and follow-up strategies in preschoolers. In an accompanying study, we are recruiting children aged 3-10 with hearing loss or normal hearing, to test different ways of screening for hearing loss. Participants will be compensated for their time. This study will help us better identify hearing loss in preschoolers so they can receive appropriate intervention and be ready for school entry.

Eligiibility: children aged 3-10 years of age with permanent hearing loss, or with normal hearing.

Study Number

15-16293

Contact

Phone: (415) 530-0830
 

 

Impact of unilateral hearing loss and mild to moderate bilateral hearing loss on language proficiency in bilingual children

Hearing loss is a major cause of speech, language, and educational delay. Hearing loss is more prevalent in non-white ethnic groups, and children whose home language is not English have increased risk for language and educational challenges. In this study, we are examining speech, language, educational, and behavioral outcomes in children who are deaf or hard of hearing and whose home language is not English. By identifying the specific challenges that this group has, we hope to develop targeted interventions to improve outcomes.

Eligiibility: children aged 6-17 years of age with mild-to-moderate OR single-sided permanent hearing loss, whose home language is not English.

Study Number

15-17261

Contact

Phone: (415) 530-0830
 

Development of an Infant/Toddler Hearing-Related Quality of Life Survey Instrument

A new diagnosis of hearing loss is challenging for parents. Learning how to manage many different options for intervention, the medical and community service systems, and a new infant or toddler who may have communication difficulties is taxing to a family's quality of life. In this study, we are interviewing medical, service, and educational providers for deaf and hard-of-hearing infants and toddlers, as well as the parents themselves, to learn how their child's hearing affects the quality of life of the child him/herself, as well as the family unit. From this, we aim to design and validate a survey instrument to measure quality of life in this population. This instrument will help us and others measure how different multidisciplinary interventions help a family and child manage hearing loss.

Eligibility: Deaf and hard-of-hearing children aged 6 months-3 years, with English-speaking parents.

Study Number

15-16760

Contact

Phone: (415) 530-0830

 

 

Rhinology and Sinus Surgery

Tissue immune interaction in nasal polyposis (TIP)

A Study of RhinAer ARC Stylus for Treating Chronic Rhinitis (RELIEF)