Epstein Laboratory Recent Publications

Auditory Prosthesis Research

Auditory Prosthesis Development

Middlebrooks JC, Snyder RL. Intraneural stimulation for auditory prosthesis: modiolar trunk and intracranial stimulation sites. Hear. Res 2008 Aug;242(1-2):52-63.

Rebscher SJ, Hetherington A, Bonham B, Wardrop P, Whinney D, Leake PA. Considerations for design of future cochlear implant electrode arrays: electrode array stiffness, size, and depth of insertion. J Rehabil Res Dev 2008;45(5):731-747.

Rebscher SJ, Hetherington AM, Snyder RL, Leake PA, Bonham BH. Design and fabrication of multichannel cochlear implants for research. J. Neurosci. Methods 2007 Oct;166(1):1-12.

Stakhovskaya O, Sridhar D, Bonham BH, Leake PA. Frequency map for the human cochlear spiral ganglion: implications for cochlear implants. J. Assoc. Res. Otolaryngol 2007 Jun;8(2):220-233.

Middlebrooks JC, Snyder RL. Auditory prosthesis with a penetrating nerve array. J. Assoc. Res. Otolaryngol 2007 Jun;8(2):258-279.

Sridhar D, Stakhovskaya O, Leake PA. A frequency-position function for the human cochlear spiral ganglion. Audiol. Neurootol 2006;11 Suppl 1:16-20.

Wardrop P, Whinney D, Rebscher SJ, Roland JT, Luxford W, Leake PA. A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. I: Comparison of Nucleus banded and Nucleus Contour electrodes. Hear. Res 2005 May;203(1-2):54-67.

The Role of Chemical Neurotrophic Factors along with Electrical Stimulation with a Cochlear Implant in Maintaining the Spiral Ganglion Neurons

Leake PA, Stakhovskaya O, Hradek GT, Hetherington AM. Factors influencing neurotrophic effects of electrical stimulation in the deafened developing auditory system. Hear. Res 2008 Aug;242(1-2):86-99.

Leake PA, Hradek GT, Vollmer M, Rebscher SJ. Neurotrophic effects of GM1 ganglioside and electrical stimulation on cochlear spiral ganglion neurons deafened as neonates. J. Comp. Neurol 2007 Apr;501(6):837-853.

Osofsky MR, Moore CM, Leake PA. Does exogenous GM1 ganglioside enhance the effects of electrical stimulation in ameliorating degeneration after neonatal deafness? Hear. Res 2001 Sep;159(1-2):23-35.

Functional Responses of the Central Auditory System to Electrical Stimulation with a Cochlear Implant

Snyder RL, Middlebrooks JC, Bonham BH. Cochlear implant electrode configuration effects on activation threshold and tonotopic selectivity. Hear. Res 2008 Jan;235(1-2):23-38.

Snyder RL, Bierer JA, Middlebrooks JC. Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulation. J. Assoc. Res. Otolaryngol 2004 Sep;5(3):305-322.

Vollmer M, Beitel RE, Snyder RL. Auditory detection and discrimination: psychophysical and neural thresholds for intracochlear electrical signals. J. Neurophysiol 2001 Nov;86(5):2330-2343.

Leake PA, Snyder RL, Rebscher SJ, Moore CM, Vollmer M. Plasticity in central representations in the inferior colliculus induced by chronic single- vs. two-channel electrical stimulation by a cochlear implant after neonatal deafness. Hear. Res 2000 Sep;147(1-2):221-241.

Snyder RL, Vollmer M, Moore CM, Rebscher SJ, Leake PA, Beitel RE. Responses of inferior colliculus neurons to amplitude-modulated intracochlear electrical pulses. J. Neurophysiol 2000 Jul;84(1):166-183.

Beitel RE, Snyder RL, Schreiner CE, Raggio MW, Leake PA. Electrical cochlear stimulation: comparisons between psychophysical and central auditory neuronal thresholds. J. Neurophysiol 2000 Apr;83(4):2145-2162.

Beitel RE, Vollmer M, Snyder RL, Schreiner CE, Leake PA. Behavioral and neurophysiological thresholds for electrical cochlear stimulation. Audiol. Neurootol 2000 Feb;5(1):31-38.

Changes in the Central Auditory System Caused by Deafness or Electrical Stimulation with a Cochlear Implant

Stakhovskaya O, Hradek GT, Snyder RL, Leake PA. Effects of age at onset of deafness and electrical stimulation on the developing cochlear nucleus. Hear. Res 2008 Sep;243(1-2):69-77.

Leake PA, Hradek GT, Bonham BH, Snyder RL. Topography of auditory nerve projections to the cochlear nucleus after neonatal deafness and electrical stimulation by a cochlear implant. J. Assoc. Res. Otolaryngol 2008 Sep;9(3):349-372.

Vollmer M, Beitel RE, Snyder RL, Leake PA. Spatial selectivity to intracochlear electrical stimulation in the inferior colliculus is degraded after long-term deafness. J. Neurophysiol 2007 Nov;98(5):2588-2603.

Leake PA, Hradek GT, Chair L, Snyder RL. Neonatal deafness results in degraded topographic specificity of auditory nerve projections to the cochlear nucleus. J. Comp. Neurol 2006 Jul;497(1):13-31.

Vollmer M, Leake PA, Beitel RE, Rebscher SJ, Snyder RL. Degradation of temporal resolution in the auditory midbrain after prolonged deafness is reversed by electrical stimulation of the cochlea. J. Neurophysiol 2005 Jun;93(6):3339-3355.

Moore CM, Vollmer M, Leake PA, Snyder RL, Rebscher SJ. The effects of chronic intracochlear electrical stimulation on inferior colliculus spatial representation. Hear. Res 2002 Feb;164(1-2):82-96.

Rebscher SJ, Snyder RL, Leake PA. The effect of electrode configuration and duration of deafness on threshold and selectivity of responses to intracochlear electrical stimulation. J. Acoust. Soc. Am 2001 May;109(5 Pt 1):2035-2048.

Reviews

Bonham BH, Litvak LM. Current focusing and steering: modeling, physiology, and psychophysics. Hear. Res 2008 Aug;242(1-2):141-153.

Middlebrooks JC, Bierer JA, Snyder RL. Cochlear implants: the view from the brain. Curr. Opin. Neurobiol 2005 Aug;15(4):488-493.

Other Auditory System Research (not Involving Cochlear Implants)

Function and Plasticity of the Central Auditory System

Cheung SW, Bonham BH, Schreiner CE, Godey B, Copenhaver DA. Realignment of interaural cortical maps in asymmetric hearing loss. J. Neurosci 2009 May;29(21):7065-7078.

Sumner CJ, Scholes C, Snyder RL. Retuning of inferior colliculus neurons following spiral ganglion lesions: a single-neuron model of converging inputs. J. Assoc. Res. Otolaryngol 2009 Mar;10(1):111-130.

Snyder RL, Bonham BH, Sinex DG. Acute changes in frequency responses of inferior colliculus central nucleus (ICC) neurons following progressively enlarged restricted spiral ganglion lesions. Hear. Res 2008 Dec;246(1-2):59-78.

Strata F, deIpolyi AR, Bonham BH, Chang EF, Liu RC, Nakahara H, Merzenich MM. Perinatal anoxia degrades auditory system function in rats. Proc. Natl. Acad. Sci. U.S.A 2005 Dec;102(52):19156-19161.

Godey B, Atencio CA, Bonham BH, Schreiner CE, Cheung SW. Functional organization of primary auditory cortex: responses to frequency-modulation sweeps. J. Neurophysiol 2005 Aug;94(2):1299-1311.

Philibert B, Beitel RE, Nagarajan SS, Bonham BH, Schreiner CE, Cheung SW. Functional organization and hemispheric comparison of primary auditory cortex (Callithrix jacchus). J. Comp. Neurol 2005 Jul;487(4):391-406.

Snyder RL, Sinex DG. Immediate changes in tuning of inferior colliculus neurons following acute lesions of the spiral ganglion. J. Neurophysiol 2002 Jan;87(1):434-452.

Snyder RL, Sinex DG, McGee JD, Walsh EW. Acute spiral ganglion lesions change the tuning and tonotopic organization of inferior colliculus neurons. Hear. Res 2000 Sep;147(1-2):200-220.

Development of the Auditory System

Jones TA, Leake PA, Snyder RL, Stakhovskaya O, Bonham B. Spontaneous discharge patterns in cochlear spiral ganglion cells before the onset of hearing. J. Neurophysiol 2007 Oct;98(4):1898-1908.

Bonham BH, Cheung SW, Godey B, Schreiner CE. Spatial organization of frequency response areas and rate/level functions in the developing AI. J. Neurophysiol 2004 Feb;91(2):841-854.

Leake PA, Snyder RL, Hradek GT. Postnatal refinement of auditory nerve projections to the cochlear nucleus. J. Comp. Neurol 2002 Jun;448(1):6-27.